日本免费黄色网址_国产又粗又大又爽大片精华液_午夜一区国产一级 片_深夜草莓视频下载APP_秋霞午夜理论2019理论中文_在线免费欧美成人亚洲_熟妇人妻av中文字幕_嫩草91久久精品中文字幕_四川小幺女国产一级毛片_波多野结衣无码在线

Many breast cancer (BC) patients suffer from complications of metastatic disease. To form metastases, cancer cells must become migratory and coordinate both invasive and proliferative programs at distant organs. Here, we identify srGAP1 as a regulator of a proliferative-to-invasive switch in BC cells. High-resolution light-sheet microscopy demonstrates that BC cells can form actin-rich protrusions during extravasation. srGAP1low cells display a motile and invasive phenotype that facilitates their extravasation from blood vessels, as shown in zebrafish and mouse models, while attenuating tumor growth. Interestingly, a population of srGAP1low cells remain as solitary disseminated tumor cells in the lungs of mice bearing BC tumors. Overall, srGAP1low cells have increased Smad2 activation and TGF-β2 secretion, resulting in increased invasion and p27 levels to sustain quiescence. These findings identify srGAP1 as a mediator of a proliferative to invasive phenotypic switch in BC cells in vivo through a TGF-β2-mediated signaling axis.Copyright ? 2022 The Authors. Published by Elsevier Inc. All rights reserved.

原文鏈接：http://www.ncbi.nlm.nih.gov/pubmed/36130489