日本免费黄色网址_国产又粗又大又爽大片精华液_午夜一区国产一级 片_深夜草莓视频下载APP_秋霞午夜理论2019理论中文_在线免费欧美成人亚洲_熟妇人妻av中文字幕_嫩草91久久精品中文字幕_四川小幺女国产一级毛片_波多野结衣无码在线

Microplastics (MPs) alone may endanger the health and fitness of aquatic species through different mechanisms. However, the harmful effects of these when mixed with other emerging contaminants require additional research. Herein, we aimed to determine whether a mixture of MPs with metformin (MET) or guanylurea (GUA) might induce embryotoxicity and oxidative stress in Danio rerio. Upon exposure to mixtures, our results showed MPs reduced the mortality rate of MET and GUA in embryos. Moreover, the severity and the rate of malformations were also decreased in all mixtures with MPs. Concerning oxidative stress, our findings indicated MET, GUA, MPs, and the mixtures increased the levels of lipoperoxidation, hydroperoxide content, and protein carbonyl content in D. rerio larvae. However, the oxidative damage induced in all mixtures was lower than that produced by both drugs alone. Thus, it is likely that the accumulation of MPs avoided the entrance of MET and GUA into the embryos. Once the embryo hatched, MPs did only remain accumulated in the yolk sac of larvae and did not translocate to other organs. Our risk assessment analysis confirmed that MPs shrunk the damage produced by MET and GUA. In a nutshell, MPs mitigate the embryotoxic damage of metformin and guanylurea in D. rerio by blocking their entrance.Copyright ? 2022. Published by Elsevier B.V.

原文鏈接：http://www.ncbi.nlm.nih.gov/pubmed/36058320